{"id":1281,"date":"2021-07-13T10:59:38","date_gmt":"2021-07-13T09:59:38","guid":{"rendered":"http:\/\/laserphotonics.uk\/?p=1281"},"modified":"2021-07-13T11:08:43","modified_gmt":"2021-07-13T10:08:43","slug":"cell-refractive-index-for-cell-biology-and-disease-diagnosis-past-present-and-future","status":"publish","type":"post","link":"https:\/\/laserphotonics.uk\/?p=1281","title":{"rendered":"Cell refractive index for cell biology and disease diagnosis: past, present and future"},"content":{"rendered":"\n<p>Cell refractive index is a key biophysical parameter, which has been extensively studied. It is correlated withother cell biophysical properties including mechanical,electrical and optical properties, and not only repre-sents the intracellular mass and concentration of a cell,but also provides important insight for various biolog-ical models. Measurement techniques developed earlieronly measure the effective refractive index of a cellor a cell suspension, providing only limited information on cell refractive index and hence hindering its in-depth analysis and correlation. Recently, the emergenceof microfluidic, photonic and imaging technologieshas enabled the manipulation of a single cell and the 3D refractive index of a single cell down to sub-micronresolution, providing powerfultoolstostudycellsbasedonrefractiveindex.Inthisreview,weprovideanoverview of cell refractive index models and measurement techniques includingmicrofluidic chip-basedtechniques for the last 50 years, present the applications and significance of cell refractive index in cell biol-ogy, hematology, and pathology, and discuss future research trends in the field, including 3D imagingmethods, integration with microfluidics and potential applications in new and breakthrough research areas.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"563\" height=\"230\" src=\"https:\/\/laserphotonics.uk\/wp-content\/uploads\/2021\/07\/image.png\" alt=\"\" class=\"wp-image-1284\" srcset=\"https:\/\/laserphotonics.uk\/wp-content\/uploads\/2021\/07\/image.png 563w, https:\/\/laserphotonics.uk\/wp-content\/uploads\/2021\/07\/image-300x123.png 300w\" sizes=\"(max-width: 563px) 100vw, 563px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-file\"><a href=\"https:\/\/laserphotonics.uk\/wp-content\/uploads\/2021\/07\/Cell-refractive-index-for-cell-biology-and-disease-diagnosis_-past-present-and-future-_-Enhanced-Reader.pdf\">Cell-refractive-index-for-cell-biology-and-disease-diagnosis_-past-present-and-future-_-Enhanced-Reader<\/a><a href=\"https:\/\/laserphotonics.uk\/wp-content\/uploads\/2021\/07\/Cell-refractive-index-for-cell-biology-and-disease-diagnosis_-past-present-and-future-_-Enhanced-Reader.pdf\" class=\"wp-block-file__button\" download>Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cell refractive index is a key biophysical parameter, which has been extensively studied. It is correlated withother cell biophysical properties including mechanical,electrical and optical properties, and not only repre-sents the intracellular mass and concentration of a cell,but also provides important insight for various biolog-ical models. Measurement techniques developed earlieronly measure the effective refractive index of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[15],"tags":[],"_links":{"self":[{"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=\/wp\/v2\/posts\/1281"}],"collection":[{"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1281"}],"version-history":[{"count":2,"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=\/wp\/v2\/posts\/1281\/revisions"}],"predecessor-version":[{"id":1285,"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=\/wp\/v2\/posts\/1281\/revisions\/1285"}],"wp:attachment":[{"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/laserphotonics.uk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}